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Article

Anthrax lethal factor and edema factor act on conserved targets in Drosophila.

Proceedings of the National Academy of Sciences of the United States of America - 28 Feb 2006

Guichard Annabel, Park Jin Mo, Cruz-Moreno Beatriz, Karin Michael, Bier Ethan

Abstract excerpt

Many bacterial toxins act on conserved components of essential host-signaling pathways. One consequence of this conservation is that genetic model organisms such as Drosophila melanogaster can be used for analyzing the mechanism of toxin action. In this study, we characterize the activities of two anthrax virulence factors, lethal factor (LF) and edema factor, in transgenic Drosophila. LF is a zinc...

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Identifiers

PMID: 16455799
DOI: 10.1073/pnas.0510748103
PMCID: PMC1413899

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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