Correlation between gene expression of aryl hydrocarbon receptor (AhR), hydrocarbon receptor nuclear translocator (Arnt), cytochromes P4501A1 (CYP1A1) and 1B1 (CYP1B1), and inducibility of CYP1A1 and CYP1B1 in human lymphocytes.

doi:10.1093/toxsci/71.1.20

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Article

Correlation between gene expression of aryl hydrocarbon receptor (AhR), hydrocarbon receptor nuclear translocator (Arnt), cytochromes P4501A1 (CYP1A1) and 1B1 (CYP1B1), and inducibility of CYP1A1 and CYP1B1 in human lymphocytes.

Toxicological sciences : an official journal of the Society of Toxicology - 1 Jan 2003

Lin Pinpin, Hu Suh-Woan, Chang Tzu-Hua

Abstract excerpt

The relationships between gene expression of aryl hydrocarbon receptor (AhR), aryl hydrocarbon receptor nuclear translocator (Arnt), cytochromes P4501A1 (CYP1A1), 1B1 (CYP1B1), CYP1A1, and the inducibility of CYP1A1 and CYP1B1 were determined in 32 cultivated human lymphocytes. Cytochrome P450 induction was performed by incubating lymphocytes with benzanthracene. The relative gene expression levels were...

Topics

Adult
Aryl Hydrocarbon Hydroxylases
Aryl Hydrocarbon Receptor Nuclear Translocator
Benz(a)Anthracenes
Cells, Cultured
Cytochrome P-450 CYP1A1
Cytochrome P-450 CYP1B1
DNA-Binding Proteins
Enzyme Induction
Female
Gene Expression Regulation, Enzymologic

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genetic Variation

Humans

Lymphocytes

Male

RNA, Messenger

Receptors, Aryl Hydrocarbon

Reverse Transcriptase Polymerase Chain Reaction

Source

Open in PubMed

Identifiers

PMID: 12520072
DOI: 10.1093/toxsci/71.1.20

Provenance

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