Article
Sex differences in risk of lung cancer: Expression of genes in the PAH bioactivation pathway in relation to smoking and bulky DNA adducts.
International journal of cancer - 15 Aug 2006
Mollerup Steen, Berge Gisle, Baera Rita, Skaug Vidar, Hewer Alan, Phillips David H, Stangeland Lodve, Haugen Aage
Abstract excerpt
It is controversial whether women have a higher lung cancer susceptibility compared to men. We previously reported higher levels of smoking-related bulky DNA adducts in female lungs. In a pilot study (27 cases), we also found a higher level of female lung cytochrome P4501A1 (CYP1A1) gene expression. In the present extended study we report on the pulmonary expression of several genes involved in polycyclic...
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