Article
The relationship between CYP1A1 aryl hydrocarbon hydroxylase activity and lung cancer in a Japanese population.
Pharmacogenetics - 1 Aug 1998
Kiyohara C, Nakanishi Y, Inutsuka S, Takayama K, Hara N, Motohiro A, Tanaka K, Kono S, Hirohata T
Abstract excerpt
Because aryl hydrocarbon hydroxylase (AHH) is considered to be responsible for the activation of benzo(a)pyrene and other polyaromatic hydrocarbons in cigarette smoke to carcinogens, it is important to examine CYP1A1 (AHH) activity in the determination of susceptibility to lung cancer. We investi...
Topics
- Adult
- Aged
- Aged, 80 and over
- Aryl Hydrocarbon Hydroxylases
- Cytochrome P-450 CYP1A1
- Enzyme Induction
- Female
- Gene Frequency
- Genotype
- Humans
- Japan
- Lung Neoplasms
- Male
- Middle Aged
- Neoplasm Staging
- Phenotype
- Polymorphism, Genetic
- Regression Analysis