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Article

Secondary heavy chain rearrangement: a mechanism for generating anti-double-stranded DNA B cells.

The Journal of experimental medicine - 6 Jan 2003

Sekiguchi Debora R, Eisenberg Robert A, Weigert Martin

Abstract excerpt

The chronic graft-versus-host (cGVH) reaction results in a syndrome that closely resembles systemic lupus erythematosus (SLE). It is induced in nonautoimmune mice by the transfer of alloreactive T cells. The availability of anti-DNA transgenes allows us to study the genetic origins of autoantibodies in this model. We induced cGVH in two anti-DNA H chain site-directed transgenic mouse strains. This resulted in...

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Source

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Identifiers

PMID: 12515811
DOI: 10.1084/jem.20020737
PMCID: PMC2193805

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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