Article
Structure/Function Analysis of Recurrent Mutations in SETD2 Protein Reveals a Critical and Conserved Role for a SET Domain Residue in Maintaining Protein Stability and Histone H3 Lys-36 Trimethylation.
The Journal of biological chemistry - 30 Sept 2016
Hacker Kathryn E, Fahey Catherine C, Shinsky Stephen A, Chiang Yun-Chen J, DiFiore Julia V, Jha Deepak Kumar, Vo Andy H, Shavit Jordan A, Davis Ian J, Strahl Brian D, Rathmell W Kimryn
Abstract excerpt
The yeast Set2 histone methyltransferase is a critical enzyme that plays a number of key roles in gene transcription and DNA repair. Recently, the human homologue, SETD2, was found to be recurrently mutated in a significant percentage of renal cell carcinomas, raising the possibility that the activity of SETD2 is tumor-suppressive. Using budding yeast and human cell line model systems, we examined the functional...
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