Article
TA repeat variation, Npr1 expression, and blood pressure: impact of the Ace locus.
Hypertension (Dallas, Tex. : 1979) - 1 Jan 2003
Tremblay Johanne, Hum David H F, Sanchez Rocio, Dumas Pierre, Pravenec Michal, Krenova Drahomira, Kren Vladimir, Kunes Jaroslav, Pausova Zdenka, Gossard Francis, Hamet Pavel
Abstract excerpt
The activity of the atrial natriuretic peptide receptor (Npr1) is altered in spontaneously hypertensive rats (SHR) in relation to its mRNA levels, suggesting abnormal transcriptional control in hypertension. A single-stranded conformational polymorphism caused by a repetitive dinucleotide segment of 10 TA in BN-Lx and of 40 TA in SHR was localized at position -943 relative to the transcription start site of the...
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