Article
A functional 12T-insertion polymorphism in the ATP1A1 promoter confers decreased susceptibility to hypertension in a male Sardinian population.
PloS one - 1 Jan 2015
Herrera Victoria L, Pasion Khristine A, Moran Ann Marie, Zaninello Roberta, Ortu Maria Francesca, Fresu Giovanni, Piras Daniela Antonella, Argiolas Giuseppe, Troffa Chiara, Glorioso Valeria, Masala Wanda, Glorioso Nicola, Ruiz-Opazo Nelson
Abstract excerpt
Identification of susceptibility genes for essential hypertension in humans has been a challenge due to its multifactorial pathogenesis complicated by gene-gene and gene-environment interactions, developmental programing and sex specific differences. These concurrent features make identification of causal hypertension susceptibility genes with a single approach difficult, thus requiring multiple lines of evidence...
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