Article
A novel variable number of tandem repeat of the natriuretic peptide precursor B gene's 5'-flanking region is associated with essential hypertension among Japanese females.
International journal of medical sciences - 16 May 2007
Kosuge Kotoko, Soma Masayoshi, Nakayama Tomohiro, Aoi Noriko, Sato Mikano, Izumi Yoichi, Matsumoto Koichi
Abstract excerpt
BACKGROUND: Brain natriuretic peptide (BNP) acts primarily as a cardiac hormone; it is produced by the ventricle and has both vasodilatory and natriuretic actions. Therefore, the BNP gene is thought to be a candidate gene for essential hypertension (EH). The present study identified variants in the 5'-flanking region of natriuretic peptide precursor B (NPPB) gene and assessed the relationship between gene...
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