Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Identification of I kappa BL as the second major histocompatibility complex-linked susceptibility locus for rheumatoid arthritis.

American journal of human genetics - 1 Feb 2003

Okamoto Koichi, Makino Satoshi, Yoshikawa Yoko, Takaki Asumi, Nagatsuka Yumie, Ota Masao, Tamiya Gen, Kimura Akinori, Bahram Seiamak, Inoko Hidetoshi

Abstract excerpt

Rheumatoid arthritis (RA) is a chronic inflammatory joint disease with a complex etiology in which environmental factors within a genetically susceptible host maneuver the innate and adaptive arms of the immune system toward recognition of autoantigens. This ultimately leads to joint destruction and clinical symptomatology. Despite the identification of a number of disease-susceptibility regions across the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Arthritis, Rheumatoid
Share to Chromosome Mapping

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Linkage

Share to HLA-DR Antigens

Share to Major Histocompatibility Complex

Share to Microsatellite Repeats

Share to Promoter Regions, Genetic

Share to Tumor Necrosis Factor-alpha

Source

Open in PubMed Open full text

Identifiers

PMID: 12509789
DOI: 10.1086/346067
PMCID: PMC379224

Genes

MICB
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Identification of I kappa BL as the second major histocompatibility complex-linked susceptibility locus for rheumatoid arthritis.PMID 12509789Read ↗

A second susceptibility gene for developing rheumatoid arthritis in the human MHC is localized within a 70-kb interval telomeric of the TNF genes in the HLA class III region.Semantic proximity Read ↗

Genetic association of the major histocompatibility complex with rheumatoid arthritis implicates two non-DRB1 loci.Semantic proximity Read ↗

Gene discovery in rheumatoid arthritis highlights the CD40/NF-kappaB signaling pathway in disease pathogenesis.Semantic proximity Read ↗

MHC class I chain-related gene B (MICB) is associated with rheumatoid arthritis susceptibility.Semantic proximity Read ↗

Fine mapping of the MHC Class III region demonstrates association of AIF1 and rheumatoid arthritis.Semantic proximity Read ↗

REL, encoding a member of the NF-kappaB family of transcription factors, is a newly defined risk locus for rheumatoid arthritis.Semantic proximity Read ↗

Analysis of single-nucleotide polymorphisms in Japanese rheumatoid arthritis patients shows additional susceptibility markers besides the classic shared epitope susceptibility sequences.Semantic proximity Read ↗

Tumor necrosis factor alpha 5'-flanking region, tumor necrosis factor receptor II, and HLA-DRB1 polymorphisms in Japanese patients with rheumatoid arthritis.Semantic proximity Read ↗

Identification of the NF-κB activating protein-like locus as a risk locus for rheumatoid arthritis.Semantic proximity Read ↗

The MHC2TA -168A/G polymorphism and risk for rheumatoid arthritis: a meta-analysis of 6861 patients and 9270 controls reveals no evidence for association.Semantic proximity Read ↗

Dissection of class III major histocompatibility complex haplotypes associated with rheumatoid arthritis.Semantic proximity Read ↗

Novel single nucleotide polymorphisms of the human nuclear factor kappa-B 2 gene identified by sequencing the entire gene.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.