Article
The MHC2TA -168A/G polymorphism and risk for rheumatoid arthritis: a meta-analysis of 6861 patients and 9270 controls reveals no evidence for association.
Annals of the rheumatic diseases - 1 Jul 2008
Bronson P G, Criswell L A, Barcellos L F
Abstract excerpt
BACKGROUND: An association between major histocompatibility complex (MHC) genes, particularly those within the class II HLA region, and rheumatoid arthritis (RA) is well established, and accounts for an estimated 30% of the genetic component in RA. The MHC class II transactivator gene (MHC2TA) on chromosome 16p13 has recently emerged as the most important transcription factor regulating genes required for class...
Topics
- Arthritis, Rheumatoid
- Gene Frequency
- Genetic Predisposition to Disease
- Genotype
- Humans
- Nuclear Proteins
- Polymorphism, Genetic
- Promoter Regions, Genetic
- Trans-Activators