Article
Analysis of single-nucleotide polymorphisms in Japanese rheumatoid arthritis patients shows additional susceptibility markers besides the classic shared epitope susceptibility sequences.
Arthritis and rheumatism - 1 Jan 2004
Kochi Yuta, Yamada Ryo, Kobayashi Kyoko, Takahashi Atsushi, Suzuki Akari, Sekine Akihiro, Mabuchi Akihiko, Akiyama Fumihiro, Tsunoda Tatsuhiko, Nakamura Yusuke, Yamamoto Kazuhiko
Abstract excerpt
OBJECTIVE: To examine the entire HLA region for loci (other than the DRB1 locus) associated with rheumatoid arthritis (RA) susceptibility, by typing HLA-DRB1 alleles and multiple single-nucleotide polymorphisms (SNPs) in the Japanese population. METHODS: The HLA-DRB1 alleles and 88 SNPs distributed over the HLA gene complex were genotyped, for 828 patients with RA and 1,032 control subjects. The data were...
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