Article
Beta cell neogenesis from ducts and phenotypic conversion of residual islet cells in the adult pancreas of glucose intolerant mice induced by selective alloxan perfusion.
Endocrine journal - 1 Oct 2002
Li Ming, Miyagawa Jun-ichiro, Yamamoto Koji, Moriwaki Makoto, Imagawa Akihisa, Iwahashi Hiromi, Yamagata Kazuya, Tochino Yoshihiro, Hanafusa Toshiaki, Matsuzawa Yuji
Abstract excerpt
The aim of this study was to clarify the pattern of beta cell neogenesis in the alloxan-perfused, beta cells-depleted segment of glucose intolerant mice induced by selective alloxan perfusion. First, duct cells proliferated in the perfused segment, then cells co-expressing multiple islet hormones and transcription factors such as PDX-1, Nkx2.2, Isl1, and Pax6 were observed in duct cells, and newly formed...
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