Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The Derivation of Highly Germline-Competent Embryonic Stem Cells Containing NOD-Derived Genome

1 Jan 2003

Abstract excerpt

It would be extremely advantageous to the analysis of disease mechanisms in the spontaneous mouse model of type 1 diabetes, the nonobese diabetic (NOD) strain, if genes in this strain could be modified in vivo using embryonic stem (ES) cells and homologous recombination. However, a NOD ES cell line with adequate germline transmission has not yet been reported. We report the development of highly...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Diabetes and associated disorders
Share to Pancreatic function and diabetes
Share to Pluripotent Stem Cells Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 12502514
DOI: 10.2337/diabetes.52.1.205

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Derivation of Highly Germline-Competent Embryonic Stem Cells Containing NOD-Derived GenomePMID 12502514Read ↗

Male germline and embryonic stem cell lines from NOD mice: efficient derivation of GS cells from a nonpermissive strain for ES cell derivation.Semantic proximity Read ↗

Validated germline-competent embryonic stem cell lines from nonobese diabetic miceSemantic proximity Read ↗

Generation of stable pluripotent stem cells from NOD mouse tail-tip fibroblasts.Semantic proximity Read ↗

Differentiation and Transplantation of Functional Pancreatic Beta Cells Generated from Induced Pluripotent Stem Cells Derived from a Type 1 Diabetes Mouse ModelSemantic proximity Read ↗

NOD x 129.H2(g7) backcross delineates 129S1/SvImJ-derived genomic regions modulating type 1 diabetes development in mice.Semantic proximity Read ↗

Agouti C57BL/6N embryonic stem cells for mouse genetic resources.Semantic proximity Read ↗

Sleeping Beauty Transposon Mutagenesis as a Tool for Gene Discovery in the NOD Mouse Model of Type 1 Diabetes.Semantic proximity Read ↗

Production of congenic mouse strains carrying NOD-derived diabetogenic genetic intervals: an approach for the genetic dissection of complex traits.Semantic proximity Read ↗

Genetic and pathogenic basis of autoimmune diabetes in NOD miceSemantic proximity Read ↗

Efficient mouse transgenesis using Gateway-compatible ROSA26 locus targeting vectors and F1 hybrid ES cells.Semantic proximity Read ↗

A susceptibility allele from a non-diabetes-prone mouse strain accelerates diabetes in NOD congenic mice.Semantic proximity Read ↗

Mouse models of type 1 and type 2 diabetes derived from the same closed colony: genetic susceptibility shared between two types of diabetes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.