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Article

Male germline and embryonic stem cell lines from NOD mice: efficient derivation of GS cells from a nonpermissive strain for ES cell derivation.

Biology of reproduction - 1 Dec 2009

Ohta Hiroshi, Ohinata Yasuhide, Ikawa Masahito, Morioka Yuka, Sakaide Yuko, Saitou Mitinori, Kanagawa Osami, Wakayama Teruhiko

Abstract excerpt

The nonobese diabetic (NOD) mouse is a valuable model for human type 1 diabetes and the development of humanized mice. Although the importance of this mouse strain is widely recognized, its usefulness is constrained by the absence of NOD embryonic stem (ES) lines with adequate germline transmission competence. In the present study, we established two germline transmission-competent types of cell lines from NOD...

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PMID: 19726737
DOI: 10.1095/biolreprod.109.079368

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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