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Article

Sites in TM2 and 3 are critical for alcohol-induced conformational changes in GABA receptors.

Journal of neurochemistry - 1 Feb 2006

Jung Sangwook, Harris R Adron

Abstract excerpt

Abstract gamma-Aminobutyric acid type A (GABA(A)) receptors are molecular targets for alcohols. Previous work suggests that S270 and A291 residues in the transmembrane (TM) 2 and 3 domains of the GABA(A) receptor alpha subunit are components of an alcohol-binding pocket, and S270I and A291W mutants abolished ethanol potentiation. Our results showed that A295C and F296C residues in the TM3 of the GABA(A) receptor...

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Identifiers

PMID: 16405501
DOI: 10.1111/j.1471-4159.2005.03617.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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