Article
Mutations of gamma-aminobutyric acid and glycine receptors change alcohol cutoff: evidence for an alcohol receptor?
Proceedings of the National Academy of Sciences of the United States of America - 26 May 1998
Wick M J, Mihic S J, Ueno S, Mascia M P, Trudell J R, Brozowski S J, Ye Q, Harrison N L, Harris R A
Abstract excerpt
Alcohols in the homologous series of n-alcohols increase in central nervous system depressant potency with increasing chain length until a "cutoff" is reached, after which further increases in molecular size no longer increase alcohol potency. A similar phenomenon has been observed in the regulation of ligand-gated ion channels by alcohols. Different ligand-gated ion channels exhibit radically different cutoff...
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