Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Selective requirements for E2f3 in the development and tumorigenicity of Rb-deficient chimeric tissues.

Molecular and cellular biology - 1 Mar 2007

Parisi Tiziana, Yuan Tina L, Faust Ann Marie, Caron Alicia M, Bronson Roderick, Lees Jacqueline A

Abstract excerpt

The tumor suppressor function of the retinoblastoma protein pRB is largely dependent upon its capacity to inhibit the E2F transcription factors and thereby cell proliferation. Attempts to study the interplay between pRB and the E2Fs have been hampered by the prenatal death of Rb; E2f nullizygous mice. In this study, we isolated Rb; E2f3 mutant embryonic stem cells and generated Rb(-/-); E2f3(-/-) chimeric mice,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Separation
Share to Cell Transformation, Neoplastic

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Embryonic Stem Cells

Share to Neoplasms

Share to Organ Specificity

Share to Retinoblastoma Protein

Share to Thyroid Neoplasms

Source

Open in PubMed Open full text

Identifiers

PMID: 17210634
DOI: 10.1128/MCB.01854-06
PMCID: PMC1820513

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Selective requirements for E2f3 in the development and tumorigenicity of Rb-deficient chimeric tissues.PMID 17210634Read ↗

E2F3 loss has opposing effects on different pRB-deficient tumors, resulting in suppression of pituitary tumors but metastasis of medullary thyroid carcinomas.Semantic proximity Read ↗

Mutant mouse models reveal the relative roles of E2F1 and E2F3 in vivo.Semantic proximity Read ↗

Novel retinoblastoma mutation abrogating the interaction to E2F2/3, but not E2F1, led to selective suppression of thyroid tumors.Semantic proximity Read ↗

E2F4 loss suppresses tumorigenesis in Rb mutant mice.Semantic proximity Read ↗

Extensive contribution of Rb-deficient cells to adult chimeric mice with limited histopathological consequences.Semantic proximity Read ↗

Critical Roles of E2F3 in Growth and Musculo-skeletal Phenotype in Mice.Semantic proximity Read ↗

E2F3 contributes both to the inappropriate proliferation and to the apoptosis arising in Rb mutant embryos.Semantic proximity Read ↗

An Rb family-independent E2F3 transcription factor variant impairs STAT5 signaling and mammary gland remodeling during pregnancy in mice.Semantic proximity Read ↗

E2f1-3 switch from activators in progenitor cells to repressors in differentiating cells.Semantic proximity Read ↗

Determination of the physiological and pathological roles of E2F3 in adult tissuesSemantic proximity Read ↗

Rb family proteins differentially regulate distinct cell lineages during epithelial development.Semantic proximity Read ↗

Interchangeable Roles for E2F Transcriptional Repression by the Retinoblastoma Protein and p27KIP1-Cyclin-Dependent Kinase Regulation in Cell Cycle Control and Tumor Suppression.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.