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Article

E2F3 loss has opposing effects on different pRB-deficient tumors, resulting in suppression of pituitary tumors but metastasis of medullary thyroid carcinomas.

Molecular and cellular biology - 1 Sept 2003

Ziebold Ulrike, Lee Eunice Y, Bronson Roderick T, Lees Jacqueline A

Abstract excerpt

The E2F transcription factors are key downstream targets of the retinoblastoma protein (pRB) tumor suppressor. We have previously shown that E2F3 plays a critical role in mediating the mitogen-induced activation of E2F-responsive genes and contributes to both the inappropriate proliferation and t...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 12944480
DOI: 10.1128/MCB.23.18.6542-6552.2003
PMCID: PMC193688

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-12944480-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

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E2F3 loss has opposing effects on different pRB-deficient tumors, resulting in suppression of pituitary tumors but metastasis of medullary thyroid carcinomas.PMID 12944480Read ↗

Selective requirements for E2f3 in the development and tumorigenicity of Rb-deficient chimeric tissues.Semantic proximity Read ↗

Mutant mouse models reveal the relative roles of E2F1 and E2F3 in vivo.Semantic proximity Read ↗

Novel retinoblastoma mutation abrogating the interaction to E2F2/3, but not E2F1, led to selective suppression of thyroid tumors.Semantic proximity Read ↗

E2F4 loss suppresses tumorigenesis in Rb mutant mice.Semantic proximity Read ↗

Loss of E2F-1 reduces tumorigenesis and extends the lifespan of Rb1(+/-)mice.Semantic proximity Read ↗

Interchangeable Roles for E2F Transcriptional Repression by the Retinoblastoma Protein and p27KIP1-Cyclin-Dependent Kinase Regulation in Cell Cycle Control and Tumor Suppression.Semantic proximity Read ↗

Determination of the physiological and pathological roles of E2F3 in adult tissuesSemantic proximity Read ↗

E2F3 contributes both to the inappropriate proliferation and to the apoptosis arising in Rb mutant embryos.Semantic proximity Read ↗

Deregulated E2F Activity Induces Hyperplasia and Senescence-Like Features in the Mouse Pituitary GlandSemantic proximity Read ↗

Critical Roles of E2F3 in Growth and Musculo-skeletal Phenotype in Mice.Semantic proximity Read ↗

An unliganded thyroid hormone beta receptor activates the cyclin D1/cyclin-dependent kinase/retinoblastoma/E2F pathway and induces pituitary tumorigenesis.Semantic proximity Read ↗

Specificity of E2F1, E2F2, and E2F3 in mediating phenotypes induced by loss of Rb.Semantic proximity Read ↗

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