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Article

DNA repair and tumorigenesis: lessons from hereditary cancer syndromes.

Cancer biology & therapy - 1 Jan 2000

Heinen Christopher D, Schmutte Christoph, Fishel Richard

Abstract excerpt

The discovery that alterations of the DNA mismatch repair system (MMR) were linked to the common human cancer susceptibility syndrome hereditary nonpolyposis colon cancer (HNPCC) resulted in the declaration of a third class of genes involved in tumor development. In addition to oncogenes and tumor suppressors, alterations of DNA repair genes involved in maintaining genomic stability were found to be a clear cause...

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Share to Base Pair Mismatch
Share to Cell Cycle
Share to Colorectal Neoplasms, Hereditary Nonpolyposis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Neoplastic Syndromes, Hereditary

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Source

Identifiers

PMID: 12496472
DOI: 10.4161/cbt.1.5.160

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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