MutS homologues hMSH4 and hMSH5: diverse functional implications in humans.

doi:10.2741/2112

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Article

MutS homologues hMSH4 and hMSH5: diverse functional implications in humans.

Frontiers in bioscience : a journal and virtual library - 1 Jan 2007

Her Chengtao, Zhao Nianxi, Wu Xiling, Tompkins Joshua D

Abstract excerpt

The DNA mismatch repair (MMR) pathway is one of the most critical genome surveillance systems for governing faithful transmission of genetic information during DNA replication. The functional necessity of this pathway in humans is partially reflected by the tight link between MMR gene mutations and the development of hereditary nonpolyposis colorectal cancer. Increasing evidence has suggested a broad involvement...

Topics

Cell Cycle Proteins
DNA Breaks, Double-Stranded
DNA Repair
Genetic Variation
Humans

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Open in PubMed

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PMID: 17127347
DOI: 10.2741/2112

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