Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Production of alpha 1,3-galactosyltransferase-deficient pigs.

Science (New York, N.Y.) - 17 Jan 2003

Phelps Carol J, Koike Chihiro, Vaught Todd D, Boone Jeremy, Wells Kevin D, Chen Shu-Hung, Ball Suyapa, Specht Susan M, Polejaeva Irina A, Monahan Jeff A, Jobst Pete M, Sharma Sugandha B, Lamborn Ashley E, Garst Amy S, Moore Marilyn, Demetris Anthony J, Rudert William A, Bottino Rita, Bertera Suzanne, Trucco Massimo, Starzl Thomas E, Dai Yifan, Ayares David L

Abstract excerpt

The enzyme alpha1,3-galactosyltransferase (alpha1,3GT or GGTA1) synthesizes alpha1,3-galactose (alpha1,3Gal) epitopes (Galalpha1,3Galbeta1,4GlcNAc-R), which are the major xenoantigens causing hyperacute rejection in pig-to-human xenotransplantation. Complete removal of alpha1,3Gal from pig organs is the critical step toward the success of xenotransplantation. We reported earlier the targeted disruption of one...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cloning, Organism
Share to Embryo Transfer

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Enterotoxins

Share to Galactosyltransferases

Share to Immunoglobulin M

Share to Islets of Langerhans Transplantation

Share to Transplantation, Heterologous

Share to Trisaccharides

Source

Open in PubMed Open full text

Identifiers

PMID: 12493821
DOI: 10.1126/science.1078942
PMCID: PMC3154759

Genes

GGTA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Production of alpha 1,3-galactosyltransferase-deficient pigs.PMID 12493821Read ↗

Production of α1,3-Galactosyltransferase-Knockout Cloned Pigs Expressing Human α1,2-Fucosylosyltransferase1Semantic proximity Read ↗

Generation of α-1,3-Galactosyltransferase-Deficient Porcine Embryonic Fibroblasts by CRISPR/Cas9-Mediated Knock-in of a Small Mutated Sequence and a Targeted Toxin-Based Selection System.Semantic proximity Read ↗

Production of alpha-1,3-galactosyltransferase null pigs by means of nuclear transfer with fibroblasts bearing loss of heterozygosity mutations.Semantic proximity Read ↗

Efficient generation of GGTA1-deficient pigs by electroporation of the CRISPR/Cas9 system into in vitro-fertilized zygotes.Semantic proximity Read ↗

Production of alpha-1,3-galactosyltransferase knockout pigs by nuclear transfer cloning.Semantic proximity Read ↗

The combinational use of <scp>CRISPR</scp>/Cas9‐based gene editing and targeted toxin technology enables efficient biallelic knockout of the α‐1,3‐galactosyltransferase gene in porcine embryonic fibroblastsSemantic proximity Read ↗

Generation of α-1,3-galactosyltransferase knocked-out transgenic cloned pigs with knocked-in five human genesSemantic proximity Read ↗

Production of alpha 1,3‐Galactosyltransferase gene‐deficient pigs by somatic cell nuclear transfer: A novel selection method for gal alpha 1,3‐Gal antigen‐deficient cellsSemantic proximity Read ↗

Efficient generation of GGTA1-null Diannan miniature pigs using TALENs combined with somatic cell nuclear transfer.Semantic proximity Read ↗

Genetically modified pigs as donors of cells, tissues, and organs for xenotransplantationSemantic proximity Read ↗

Generation of GGTA1 biallelic knockout pigs via zinc-finger nucleases and somatic cell nuclear transfer.Semantic proximity Read ↗

Production of α1,3-galactosyltransferase targeted pigs using transcription activator-like effector nuclease-mediated genome editing technologySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.