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Article

Production of alpha-1,3-galactosyltransferase knockout pigs by nuclear transfer cloning.

Science (New York, N.Y.) - 8 Feb 2002

Lai Liangxue, Kolber-Simonds Donna, Park Kwang-Wook, Cheong Hee-Tae, Greenstein Julia L, Im Gi-Sun, Samuel Melissa, Bonk Aaron, Rieke August, Day Billy N, Murphy Clifton N, Carter David B, Hawley Robert J, Prather Randall S

Abstract excerpt

The presence of galactose alpha-1,3-galactose residues on the surface of pig cells is a major obstacle to successful xenotransplantation. Here, we report the production of four live pigs in which one allele of the alpha-1,3-galactosyltransferase locus has been knocked out. These pigs were produced by nuclear transfer technology; clonal fetal fibroblast cell lines were used as nuclear donors for embryos...

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Share to Animals, Genetically Modified
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 11778012
DOI: 10.1126/science.1068228

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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