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Article

Production of alpha-1,3-galactosyltransferase null pigs by means of nuclear transfer with fibroblasts bearing loss of heterozygosity mutations.

Proceedings of the National Academy of Sciences of the United States of America - 11 May 2004

Kolber-Simonds Donna, Lai Liangxue, Watt Steven R, Denaro Maria, Arn Scott, Augenstein Monica L, Betthauser Jeffery, Carter David B, Greenstein Julia L, Hao Yanhong, Im Gi-Sun, Liu Zhonghua, Mell Greg D, Murphy Clifton N, Park Kwang-Wook, Rieke August, Ryan David J J, Sachs David H, Forsberg Erik J, Prather Randall S, Hawley Robert J

Abstract excerpt

Hyperacute rejection of porcine organs by old world primate recipients is mediated through preformed antibodies against galactosyl-alpha-1,3-galactose (Galalpha-1,3-Gal) epitopes expressed on the pig cell surface. Previously, we generated inbred miniature swine with a null allele of the alpha-1,3...

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Identifiers

PMID: 15123792
DOI: 10.1073/pnas.0307819101
PMCID: PMC409919

Genes

GGTA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-15123792-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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