Article
Comparison of levels of HIV-1 resistance to protease inhibitors by recombinant versus conventional virus phenotypic assay and two genotypic interpretation procedures in treatment-naive and HAART-experienced HIV-infected patients.
The Journal of antimicrobial chemotherapy - 1 Jan 2003
Paolucci Stefania, Baldanti Fausto, Zavattoni Maurizio, Comolli Giuditta, Labò Nazzarena, Menzo Stefano, Clementi Massimo, Gerna Giuseppe
Abstract excerpt
OBJECTIVES: To compare genotypic and phenotypic HIV-1 drug resistance assays. METHODS: Protease inhibitor (PI) susceptibility was phenotypically analysed in HIV-1 isolates and recombinant viruses expressing proteases from viral isolates. Two genotypic interpretation methods were carried out in parallel. RESULTS: Entirely concordant resistance levels were shown in 5/10 (50%) highly active anti-retroviral therapy...
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