Article
Phenotypic susceptibility to nonnucleoside inhibitors of virion-associated reverse transcriptase from different HIV types and groups.
Journal of acquired immune deficiency syndromes (1999) - 15 Dec 2004
Tuaillon Edouard, Gueudin Marie, Lemée Véronique, Gueit Isabelle, Roques Pierre, Corrigan Gary E, Plantier Jean-Christophe, Simon François, Braun Joséphine
Abstract excerpt
OBJECTIVES: To evaluate a phenotype assay based on plasma reverse transcriptase (RT) to assess HIV susceptibility to nonnucleoside RT inhibitors (NNRTIs). To compare RT-based phenotype with recombinant virus assay (RVA) phenotype- and genotype-based analysis. To assess group O and HIV-2 susceptibility to NNRTIs in correlation with genotype polymorphisms. METHODS: RT activity was quantified and its susceptibility...
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