Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Acetyltransferase p300 regulates NBS1-mediated DNA damage response.

FEBS letters - 3 Jan 2011

Jang Eun Ryoung, Choi Jae Duk, Lee Jong-Soo

Abstract excerpt

The role of p300 in DNA damage response is unclear. To understand how ATM-dependent phosphorylation of p300 affects its function in response to DNA damage, we present evidence that S106 of p300, which is phosphorylated by ATM, regulates stability of NBS1 and recruitment into damaged DNA, possibly...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acetyltransferases
Share to Ataxia Telangiectasia Mutated Proteins
Share to Immunoprecipitation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Microscopy, Confocal

Share to p300-CBP Transcription Factors

Share to Protein Stability

Share to Serine

Share to Two-Hybrid System Techniques

Source

Identifiers

PMID: 21108945
DOI: 10.1016/j.febslet.2010.11.034

Genes

ATM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-21108945-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Acetyltransferase p300 regulates NBS1-mediated DNA damage response.PMID 21108945Read ↗

Life and death of transcriptional co-activator p300Semantic proximity Read ↗

AML1 is functionally regulated through p300-mediated acetylation on specific lysine residues.Semantic proximity Read ↗

CBP/p300 acetyltransferase activity in hematologic malignancies.Semantic proximity Read ↗

Autophosphorylation at serine 1981 stabilizes ATM at DNA damage sites.Semantic proximity Read ↗

Novel function of HATs and HDACs in homologous recombination through acetylation of human RAD52 at double-strand break sitesSemantic proximity Read ↗

Dysregulation of the p300/CBP histone acetyltransferases in human cancer.Semantic proximity Read ↗

Acetylation of the human DNA glycosylase NEIL2 and inhibition of its activity.Semantic proximity Read ↗

Acetylation dynamics of human nuclear proteins during the ionizing radiation-induced DNA damage responseSemantic proximity Read ↗

Acetylation of WRN Protein Regulates Its Stability by Inhibiting UbiquitinationSemantic proximity Read ↗

DNA damage-induced acetylation of lysine 3016 of ATM activates ATM kinase activity.Semantic proximity Read ↗

Functional Interaction of H2AX, NBS1, and p53 in ATM-Dependent DNA Damage Responses and Tumor SuppressionSemantic proximity Read ↗

ATM-mediated phosphorylation of the chromatin remodeling enzyme BRG1 modulates DNA double-strand break repair.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.