Article
Interferon regulatory factor-2 regulates cell growth through its acetylation.
The Journal of biological chemistry - 11 Jul 2003
Masumi Atsuko, Yamakawa Yoshio, Fukazawa Hidesuke, Ozato Keiko, Komuro Katsutoshi
Abstract excerpt
We have previously shown that interferon regulatory factor-2 (IRF-2) is acetylated by p300 and PCAF in vivo and in vitro. In this study we identified, by mass spectrometry, two lysine residues in the DNA binding domain (DBD), Lys-75 and Lys-78, to be the major acetylation sites in IRF-2. Although acetylation of IRF-2 did not alter DNA binding activity in vitro, mutation of Lys-75 diminished the IRF-2-dependent...
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