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Article

p300 modulates ATF4 stability and transcriptional activity independently of its acetyltransferase domain.

The Journal of biological chemistry - 16 Dec 2005

Lassot Irina, Estrabaud Emilie, Emiliani Stephane, Benkirane Monsef, Benarous Richard, Margottin-Goguet Florence

Abstract excerpt

ATF4 plays a crucial role in the cellular response to stress and multiple stress responses pathways converge to the translational up-regulation of ATF4. ATF4 is a substrate of the SCF(betaTrCP) ubiquitin ligase that binds to betaTrCP through phosphorylation on a DSGXXXS motif. We show here that A...

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Source

Identifiers

PMID: 16219772
DOI: 10.1074/jbc.M505294200

Genes

ATF4

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-16219772-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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