Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

p300 modulates ATF4 stability and transcriptional activity independently of its acetyltransferase domain.

The Journal of biological chemistry - 16 Dec 2005

Lassot Irina, Estrabaud Emilie, Emiliani Stephane, Benkirane Monsef, Benarous Richard, Margottin-Goguet Florence

Abstract excerpt

ATF4 plays a crucial role in the cellular response to stress and multiple stress responses pathways converge to the translational up-regulation of ATF4. ATF4 is a substrate of the SCF(betaTrCP) ubiquitin ligase that binds to betaTrCP through phosphorylation on a DSGXXXS motif. We show here that ATF4 stability is also modulated by the histone acetyltransferase p300, which induces ATF4 stabilization by inhibiting...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Activating Transcription Factor 4
Share to Catalysis

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to CREB-Binding Protein

Share to Gene Silencing

Share to Histone Acetyltransferases

Share to Immunoprecipitation

Share to p300-CBP Transcription Factors

Share to Ubiquitin

Source

Identifiers

PMID: 16219772
DOI: 10.1074/jbc.M505294200

Genes

ATF4

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

p300 modulates ATF4 stability and transcriptional activity independently of its acetyltransferase domain.PMID 16219772Read ↗

ATF4 degradation relies on a phosphorylation-dependent interaction with the SCF(betaTrCP) ubiquitin ligase.Semantic proximity Read ↗

The common stress responsive transcription factor ATF3 binds genomic sites enriched with p300 and H3K27ac for transcriptional regulationSemantic proximity Read ↗

Life and death of transcriptional co-activator p300Semantic proximity Read ↗

Nuclear translocation of glyceraldehyde-3-phosphate dehydrogenase is regulated by acetylation.Semantic proximity Read ↗

The transcriptional coactivator and acetyltransferase p300 in fibroblast biology and fibrosisSemantic proximity Read ↗

Control of activating transcription factor 4 (ATF4) persistence by multisite phosphorylation impacts cell cycle progression and neurogenesis.Semantic proximity Read ↗

Autoacetylation regulates P/CAF nuclear localization.Semantic proximity Read ↗

SF-1 (nuclear receptor 5A1) activity is activated by cyclic AMP via p300-mediated recruitment to active foci, acetylation, and increased DNA binding.Semantic proximity Read ↗

SUMOylation of ATF3 alters its transcriptional activity on regulation of TP53 gene.Semantic proximity Read ↗

HIV-1 tat transcriptional activity is regulated by acetylation.Semantic proximity Read ↗

The acetylase activity of p300 is dispensable for MDM2 stabilization.Semantic proximity Read ↗

p300-Dependent Acetylation of Activating Transcription Factor 5 Enhances C/EBPβ Transactivation of C/EBPα during 3T3-L1 DifferentiationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.