Article
Impact of genetic background and ablation of insulin receptor substrate (IRS)-3 on IRS-2 knock-out mice.
The Journal of biological chemistry - 18 Apr 2003
Terauchi Yasuo, Matsui Junji, Suzuki Ryo, Kubota Naoto, Komeda Kajuro, Aizawa Shinichi, Eto Kazuhiro, Kimura Satoshi, Nagai Ryozo, Tobe Kazuyuki, Lienhard Gustav E, Kadowaki Takashi
Abstract excerpt
Although we and others have generated IRS-2 knock-out (IRS-2(-/-)) mice, significant differences were seen between the two lines of IRS-2(-/-) mice in the severity of diabetes and alterations of beta-cell mass. It has been reported that although IRS-1 and IRS-3 knock-out mice showed normal blood glucose levels, IRS-1/IRS-3 double knock-out mice exhibited marked hyperglycemia. Thus, IRS-1 and IRS-3 compensate each...
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