Article
ARF mutation accelerates pituitary tumor development in Rb+/- mice.
Proceedings of the National Academy of Sciences of the United States of America - 24 Dec 2002
Tsai Kenneth Y, MacPherson David, Rubinson Douglas A, Nikitin Alexander Yu, Bronson Roderick, Mercer Kim L, Crowley Denise, Jacks Tyler
Abstract excerpt
Mice heterozygous for the retinoblastoma (Rb) tumor suppressor gene develop pituitary and thyroid tumors with high penetrance. We demonstrate here that loss of the ARF tumor suppressor strongly accelerates intermediate lobe pituitary tumorigenesis in Rb heterozygous mice. These effects in the pituitary are greater than those conferred by p53 loss in that Rb+-;ARF-- mice display significantly more early atypical...
Topics
- Animals
- Cell Division
- Chromosome Mapping
- Genes, Retinoblastoma
- Genes, p53
- Loss of Heterozygosity
- Mice
- Mutation
- Pituitary Neoplasms
- Tumor Suppressor Protein p14ARF