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Article

Deregulated E2F Activity Induces Hyperplasia and Senescence-Like Features in the Mouse Pituitary Gland

14 Mar 2005

Abstract excerpt

The retinoblastoma gene, RB1, is one of the most frequently mutated genes in human cancer. Rb heterozygous mice develop pituitary tumors with 100% incidence, and the E2F transcription factors are required for this. To assess whether deregulated E2F activity is sufficient to induce pituitary tumors, we generated transgenic mice expressing an inducible E2F3 protein in the intermediate lobe of the pituitary gland....

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Identifiers

PMID: 15767672
DOI: 10.1128/mcb.25.7.2660-2672.2005

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Deregulated E2F Activity Induces Hyperplasia and Senescence-Like Features in the Mouse Pituitary GlandPMID 15767672Read ↗

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E2F3 loss has opposing effects on different pRB-deficient tumors, resulting in suppression of pituitary tumors but metastasis of medullary thyroid carcinomas.Semantic proximity Read ↗

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