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Article

The relationship between the roles of BRCA genes in DNA repair and cancer predisposition.

Trends in molecular medicine - 1 Dec 2002

Tutt Andrew, Ashworth Alan

Abstract excerpt

The proteins encoded by the breast-cancer-susceptibility genes, BRCA1 and BRCA2, have recently been implicated in DNA-repair processes, thereby improving our understanding of how the loss of these genes contributes to cancer initiation and progression. It appears that the role of BRCA1 in DNA repair, which could involve the integration of several pathways, is broader than that of BRCA2. BRCA1 functions in the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Recombination, Genetic

Source

Identifiers

PMID: 12470990
DOI: 10.1016/s1471-4914(02)02434-6

Genes

BRCA1
BRCA2
RAD51

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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