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Article

Homologous Recombination Deficiencies and Hereditary Tumors.

International journal of molecular sciences - 29 Dec 2021

Yamamoto Hideki, Hirasawa Akira

Abstract excerpt

Homologous recombination (HR) is a vital process for repairing DNA double-strand breaks. Germline variants in the HR pathway, comprising at least 10 genes, such as BRCA1, BRCA2, ATM, BARD1, BRIP1, CHEK2, NBS1(NBN), PALB2, RAD51C, and RAD51D, lead to inherited susceptibility to specific types of cancers, including those of the breast, ovaries, prostate, and pancreas. The penetrance of germline pathogenic variants...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35008774
DOI: 10.3390/ijms23010348
PMCID: PMC8745585

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