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Article

Endothelial nitric oxide synthase genotype modulates the improvement of coronary blood flow by pravastatin: a placebo-controlled PET study.

Journal of molecular medicine (Berlin, Germany) - 1 Dec 2002

Kunnas Tarja A, Lehtimäki Terho, Laaksonen Reijo, Ilveskoski Erkki, Janatuinen Tuula, Vesalainen Risto, Nuutila Pirjo, Karhunen Pekka J, Knuuti Juhani, Nikkari Seppo T

Abstract excerpt

The objective was to study whether coronary blood flow or its response to pravastatin are affected by genetic variation in the endothelial nitric oxide synthase (eNOS) gene. Vascular endothelial nitric oxide maintains endothelium-dependent vasodilatation and also mediates antithrombotic actions. Its formation is catalyzed by eNOS, a constitutive enzyme, which has a polymorphic site in intron 4 (4a/b). Some...

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Identifiers

PMID: 12483466
DOI: 10.1007/s00109-002-0398-3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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