Article
Effect of the stromelysin-1 promoter on efficacy of pravastatin in coronary atherosclerosis and restenosis.
The American journal of cardiology - 15 Mar 1999
de Maat M P, Jukema J W, Ye S, Zwinderman A H, Moghaddam P H, Beekman M, Kastelein J J, van Boven A J, Bruschke A V, Humphries S E, Kluft C, Henney A M
Abstract excerpt
It has proved difficult to identify high-risk patients for atherosclerosis and to determine how they might respond to medication. Recently, a common promoter variant of the human stromelysin-1 gene has been reported, which has been shown to affect the transcription. We investigated whether this polymorphism had any impact on the risk of events, especially restenosis and progression of coronary artery disease and...
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