Article
Interleukin-1B genotype modulates the improvement of coronary artery reactivity by lipid-lowering therapy with pravastatin: a placebo-controlled positron emission tomography study in young healthy men.
Pharmacogenetics - 1 Oct 2003
Lehtimäki Terho, Laaksonen Reijo, Janatuinen Tuula, Vesalainen Risto, Nuutila Pirjo, Mattila Kari, Ilveskoski Erkki, Luomala Mari, Saikku Pekka, Knuuti Juhani, Hurme Mikko
Abstract excerpt
A polymorphism at position -511 of interleukin-1B (IL-1B) gene promoter regulates IL-1B levels, immune and inflammatory responses and possible atherogenesis. We used positron emission tomography (PET) to study whether coronary reactivity or its response to pravastatin is related to this IL-1B polymorphism. The study comprised a randomized, double-blind, placebo-controlled trial with two treatment groups: (i)...
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