Article
Exercise training improves muscle vasodilatation in individuals with T786C polymorphism of endothelial nitric oxide synthase gene.
Physiological genomics - 1 Sept 2010
Negrao Marcelo V, Alves Cleber R, Alves Guilherme B, Pereira Alexandre C, Dias Rodrigo G, Laterza Mateus C, Mota Gloria F, Oliveira Edilamar M, Bassaneze Vinícius, Krieger Jose E, Negrao Carlos E, Rondon Maria Urbana P B
Abstract excerpt
Allele T at promoter region of the eNOS gene has been associated with an increase in coronary disease mortality, suggesting that this allele increases susceptibility for endothelial dysfunction. In contrast, exercise training improves endothelial function. Thus, we hypothesized that: 1) Muscle vasodilatation during exercise is attenuated in individuals homozygous for allele T, and 2) Exercise training improves...
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