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Article

Birc1e is the gene within the Lgn1 locus associated with resistance to Legionella pneumophila.

Nature genetics - 1 Jan 2003

Diez Eduardo, Lee Seung-Hwan, Gauthier Susan, Yaraghi Zahra, Tremblay Michel, Vidal Silvia, Gros Philippe

Abstract excerpt

In inbred mouse strains, permissiveness to intracellular replication of Legionella pneumophila is controlled by a single locus (Lgn1), which maps to a region within distal Chromosome 13 that contains multiple copies of the gene baculoviral IAP repeat-containing 1 (Birc1, also called Naip; refs. 1-3). Genomic BAC clones from the critical interval were transferred into transgenic mice to functionally complement the...

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Identifiers

PMID: 12483212
DOI: 10.1038/ng1065

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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