Article
Generation of a high-resolution genetic map and a YAC contig of the Lurcher locus on mouse chromosome 6.
Genome research - 1 Nov 1995
Zuo J, De Jager P L, Norman D J, Heintz N
Abstract excerpt
Lurcher (Lc) is a semidominant mouse mutant that displays progressive neurodegeneration during perinatal development. This genetic lesion results in apoptotic neuronal death in a dosage dependent and cell autonomous manner in specific neurons during their terminal differentiation. To understand t...
Topics
- Animals
- Base Sequence
- Blotting, Southern
- Chromosome Mapping
- Chromosomes, Artificial, Yeast
- Cloning, Molecular
- Crosses, Genetic
- DNA Primers
- Electrophoresis, Polyacrylamide Gel
- Genetic Markers
- Genotype
- Hybrid Cells
- Mice
- Mice, Neurologic Mutants
- Molecular Sequence Data
- Polymerase Chain Reaction