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Article

Lgn1, a gene that determines susceptibility to Legionella pneumophila, maps to mouse chromosome 13.

Genomics - 10 Apr 1995

Dietrich W F, Damron D M, Isberg R R, Lander E S, Swanson M S

Abstract excerpt

The intracellular pathogen Legionella pneumophila is unable to replicate in macrophages derived from most inbred mouse strains. Here, we report the mapping of a gene, called Lgn1, that determines whether mouse macrophages are permissive for the intracellular replication of L. pneumophila. Although Lgn1 has been previously reported to map to mouse chromosome 15, we show here that it actually maps to chromosome 13,...

Topics

Animals
Bone Marrow
Bone Marrow Cells
Cells, Cultured
Chromosome Mapping
Cloning, Molecular
Crosses, Genetic
Female
Genetic Predisposition to Disease
Legionella pneumophila
Legionnaires' Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Macrophages

Male

Mice

Mice, Inbred Strains

Source

Identifiers

PMID: 7607666
DOI: 10.1016/0888-7543(95)80161-e

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7607666-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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