Article
High-throughput screening for evidence of association by using mass spectrometry genotyping on DNA pools.
Proceedings of the National Academy of Sciences of the United States of America - 24 Dec 2002
Mohlke Karen L, Erdos Michael R, Scott Laura J, Fingerlin Tasha E, Jackson Anne U, Silander Kaisa, Hollstein Pablo, Boehnke Michael, Collins Francis S
Abstract excerpt
To facilitate positional cloning of complex trait susceptibility loci, we are investigating methods to reduce the effort required to identify trait-associated alleles. We examined primer extension analysis by matrix-assisted laser desorptionionization time-of-flight mass spectrometry to screen single-nucleotide polymorphisms (SNPs) for association by using DNA pools. We tested whether this method can accurately...
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