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Article

SNP allele frequency estimation in DNA pools and variance components analysis.

BioTechniques - 1 May 2004

Downes Kate, Barratt Bryan J, Akan Pelin, Bumpstead Sue J, Taylor Stacey D, Clayton David G, Deloukas Panos

Abstract excerpt

The estimation of single nucleotide polymorphism (SNP) allele frequency in pooled DNA samples has been proposed as a cost-effective approach to whole genome association studies. However, the key issue is the allele frequency window in which a genotyping method operates and provides a statistically reliable answer. We assessed the homogeneous mass extend assay and estimated the variance associated with each...

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Identifiers

PMID: 15152604
DOI: 10.2144/04365RR01

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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