Article
Effect of methylenetetrahydrofolate reductase 677C-->T polymorphism on toxicity and homocysteine plasma level after chronic methotrexate treatment of ovarian cancer patients.
International journal of cancer - 20 Jan 2003
Toffoli Giuseppe, Russo Antonio, Innocenti Federico, Corona Giuseppe, Tumolo Salvatore, Sartor Franca, Mini Enrico, Boiocchi Mauro
Abstract excerpt
MTHFR is a critical enzyme that regulates the metabolism of folate and methionine, both of which are important factors in DNA methylation and synthesis. Subjects with the 677C-->T variant have impaired remethylation of Hcy to methionine that could determine hyperhomocysteinemia. Remethylation of Hcy into methionine and DNA methylation are also affected by MTX treatment. Thus, a combined effect between MTX and...
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