Association of hyperhomocysteinemia with genetic variants in key enzymes of homocysteine metabolism and methotrexate toxicity in rheumatoid arthritis patients.

doi:10.1007/s00011-018-1161-8

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Article

Association of hyperhomocysteinemia with genetic variants in key enzymes of homocysteine metabolism and methotrexate toxicity in rheumatoid arthritis patients.

Inflammation research : official journal of the European Histamine Research Society ... [et al.] - 1 Aug 2018

Chaabane Souhir, Messedi Meriam, Akrout Rim, Ben Hamad Mariem, Turki Mouna, Marzouk Sameh, Keskes Leila, Bahloul Zouheir, Rebai Ahmed, Ayedi Fatma, Maalej Abdellatif

Abstract excerpt

OBJECTIVES: The study investigated the association between plasma homocysteine, folate and vitamin B12 with 5,10 methylenetetrahydrofolate reductase (MTHFR C677T and A1298C), thymidylate synthase (TYMS 2R → 3R) and methionine synthase (MTR A2756G) polymorphisms and methotrexate (MTX) treatment and toxicity in Tunisian Rheumatoid arthritis (RA) patients. METHODS: A total of 185 patients with RA were included....

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PMID: 29796841
DOI: 10.1007/s00011-018-1161-8

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MTHFR
MTR
TYMS

Variants

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