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Article

Methotrexate-induced mucositis in acute leukemia patients is not associated with the MTHFR 677T allele in Mexico.

Hematology (Amsterdam, Netherlands) - 1 Oct 2007

Ruiz-Argüelles Guillermo J, Coconi-Linares Lucia Nancy, Garcés-Eisele Javier, Reyes-Núñez Virginia

Abstract excerpt

Methylenetetrahydrofolate reductase (MTHFR) has two common variants with reduced activity due to polymorphisms at nucleotides 677 and 1298. Both affect folate metabolism and thus remethylation of homocysteine, but are also thought to affect nucleotide synthesis and DNA methylation. Methotrexate (MTX), which interrupts folate metabolism, is used in the treatment of a variety of diseases including acute...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17891601
DOI: 10.1080/10245330701448479

Genes

MTHFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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Methotrexate-induced mucositis in acute leukemia patients is not associated with the MTHFR 677T allele in Mexico.PMID 17891601Read ↗

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