Article
Methylenetetrahydrofolate reductase C677T and A1298C gene variants in adult non-Hodgkin's lymphoma patients: association with toxicity and survival.
Haematologica - 1 Apr 2007
Gemmati Donato, Ongaro Alessia, Tognazzo Silvia, Catozzi Linda, Federici Federica, Mauro Endri, Della Porta Matteo, Campioni Diana, Bardi Antonella, Gilli Giuseppe, Pellati Agnese, Caruso Angelo, Scapoli Gian L, De Mattei Monica
Abstract excerpt
BACKGROUND AND OBJECTIVES: Common methylenetetrahydrofolate reductase gene variants (MTHFR C677T and A1298C) have been described to have opposite effects on cancer patients. They may reduce cancer susceptibility and increase drug-related toxicity when folate antagonists (e.g. methotrexate) are utilized. We analyzed 110 patients with high-grade non-Hodgkin's lymphoma (NHL), 68 of whom were eligible for a...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.