Article
Effects of methylenetetrahydrofolate reductase and reduced folate carrier 1 polymorphisms on high-dose methotrexate-induced toxicities in children with acute lymphoblastic leukemia or lymphoma.
Journal of pediatric hematology/oncology - 1 Feb 2006
Shimasaki Noriko, Mori Tetsuya, Samejima Hazuki, Sato Reiko, Shimada Hiroyuki, Yahagi Naohisa, Torii Chiharu, Yoshihara Hiroki, Tanigawara Yusuke, Takahashi Takao, Kosaki Kenjiro
Abstract excerpt
The authors investigated whether high-dose methotrexate-induced toxicity differed according to the presence of methylenetetrahydrofolate reductase (MTHFR) or reduced folate carrier 1 (RFC1) genetic polymorphism. The authors studied 15 children with acute lymphoblastic leukemia or lymphoblastic ly...
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