Article
The C677T polymorphism in the MTHFR gene is associated with the toxicity of methotrexate in a Spanish rheumatoid arthritis population.
Scandinavian journal of rheumatology - 1 Feb 2012
Cáliz R, del Amo J, Balsa A, Blanco F, Silva L, Sanmarti R, Martínez F G, Collado M D, Ramirez M del Carmen, Tejedor D, Artieda M, Pascual-Salcedo D, Oreiro N, Andreu J L, Graell E, Simon L, Martínez A, Mulero J
Abstract excerpt
OBJECTIVE: Methotrexate (MTX) is the first-choice drug for the treatment of rheumatoid arthritis (RA) patients. However, 30% of RA patients discontinue therapy within 1 year, usually because of adverse effects. Previous studies have reported conflicting results on the association of polymorphisms in the MTHFR gene with the toxicity of MTX in RA. The aim of this study was to assess the involvement of the C677T and...
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