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Article

Rates of behavior and aging specified by mitochondrial function during development.

Science (New York, N.Y.) - 20 Dec 2002

Dillin Andrew, Hsu Ao-Lin, Arantes-Oliveira Nuno, Lehrer-Graiwer Joshua, Hsin Honor, Fraser Andrew G, Kamath Ravi S, Ahringer Julie, Kenyon Cynthia

Abstract excerpt

To explore the role of mitochondrial activity in the aging process, we have lowered the activity of the electron transport chain and adenosine 5'-triphosphate (ATP) synthase with RNA interference (RNAi) in Caenorhabditis elegans. These perturbations reduced body size and behavioral rates and extended adult life-span. Restoring messenger RNA to near-normal levels during adulthood did not elevate ATP levels and did...

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PMID: 12471266
DOI: 10.1126/science.1077780

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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